Table 4 Plasma biomarker logistic regression ROC curve, F1, and P-value.
From: A novel multiplex biomarker panel for profiling human acute and chronic kidney disease
Protein | AKI (COVID-19) versus control | CKD/ESKD versus control | ||||
|---|---|---|---|---|---|---|
ROC curve AUC (95%CI) | F1 | P-value | ROC curve AUC (95%CI) | F1 | P-value | |
KIM-1 | 1.00 (1.00–1.00) | 1.00 | 0.003 | 0.80 (0.80–0.81) | 0.80 | 0.282 |
NAG | 0.60 (0.59–0.61) | 0.32 | 1.000 | 0.51 (0.51–0.51) | 0.84 | 1.000 |
Calbindin | 0.99 (0.98–0.99) | 0.90 | 0.026 | 0.77 (0.76–0.77) | 0.81 | 0.577 |
GSTA1 | 1.00 (1.00–1.00) | 0.96 | 0.003 | 0.76 (0.76–0.77) | 0.80 | 0.666 |
Osteoactivin | 0.91 (0.91–0.92) | 0.75 | 0.062 | 0.86 (0.85–0.87) | 0.89 | 0.026 |
Renin | 1.00 (1.00–1.00) | 0.99 | 0.003 | 0.91 (0.91–0.91) | 0.88 | 0.006 |
Clusterin | 0.94 (0.93–0.94) | 0.66 | 0.039 | 0.83 (0.83–0.84) | 0.84 | 0.104 |
RBP4 | 0.50 (0.48–0.52) | 0.32 | 0.434 | 0.50 (0.49–0.52) | 0.40 | 1.000 |
IL-18 | 1.00 (1.00–1.00) | 0.96 | 0.003 | 0.92 (0.91–0.92) | 0.89 | 0.015 |
IP-10 | 1.00 (1.00–1.00) | 0.96 | 0.003 | 0.85 (0.84–0.86) | 0.88 | 0.048 |
EGF | 1.00 (1.00–1.00) | 0.99 | 0.019 | 0.77 (0.77–0.78) | 0.80 | 0.586 |
MCP-1 | 1.00 (1.00–1.00) | 0.92 | 0.003 | 0.96 (0.96–0.96) | 0.93 | < 0.001 |
VEGF-A | 1.00 (1.00–1.00) | 0.99 | 0.003 | 0.94 (0.94–0.95) | 0.93 | 0.001 |
Uromodulin | 0.73 (0.72–0.74) | 0.64 | 1.000 | 0.97 (0.97–0.97) | 0.92 | 0.003 |
α1-microglobulin | 0.64 (0.62–0.65) | 0.53 | 1.000 | 0.96 (0.96–0.97) | 0.92 | < 0.001 |
TFF3 | 0.98 (0.98–0.99) | 0.89 | 0.007 | 0.97 (0.96–0.97) | 0.96 | 0.003 |
Osteopontin | 1.00 (1.00–1.00) | 1.00 | 0.003 | 0.92 (0.91–0.92) | 0.89 | 0.005 |
Cystatin C | 0.90 (0.89–0.91) | 0.76 | 0.098 | 0.97 (0.97–0.97) | 0.94 | < 0.001 |
NGAL | 0.95 (0.95–0.96) | 0.87 | 0.023 | 0.96 (0.96–0.96) | 0.95 | < 0.001 |
β2-microglobulin | 1.00 (1.00–1.00) | 0.98 | 0.003 | 0.98 (0.98–0.98) | 0.96 | < 0.001 |
TIMP-1 | 1.00 (1.00–1.00) | 1.00 | 0.003 | 0.97 (0.97–0.97) | 0.93 | < 0.001 |
