Figure 1

(a–c) Schematics of the SAFI system based on a circular x-ray source array. Fifty-one cathodes are equally distributed on a circle and generate a circular array of focal spots on a ring-shaped anode. A multi-aperture collimator (MAC), designed based on the specific anatomy of the animal subject in treatment planning, is positioned outside the vacuum envelope and collimates the beams to the target. (d) Schematic of the beam controller design based on the multi-source x-ray tube design (electron optics and electrode voltage details are omitted). All beams are turned on simultaneously and with optimized intensity during FLASH-RT treatment, while for inverse-geometry micro-CT imaging, they are turned on sequentially.