Figure 1
Effects of PDE4 inhibition in the DH after a short retrieval session. The experimental design is represented above the graphs. The red arrows represent the moment of treatment. (A) PDE4 inhibition after retrieval did not induce any effects during Test A1. However, animals that were treated with ROF presented less freezing behavior than controls in Test A2. n: ROF = 9; VEH = 9. (B) The omission of the retrieval session abolished the effect of ROF in Test A2. n: ROF = 9; VEH = 9. (C) The omission of Test A1 24 h after the retrieval and treatments, abolished the effect of ROF in Test A2. n: ROF = 8; VEH = 8. The data is represented by mean ± S.E.M. and the individual values of the percentage of freezing expressed by animals during each session. The * represents a significant difference (*P < 0.05) compared to VEH in the same session. The # represents a significant difference (#P < 0.05) comparing the groups to themselves at previous Context A exposure.
