Figure 2
Kidney cancer cell lines show various degrees of nucleotide excision repair deficiency by a functional assay monitoring the cells’ ability to remove 6–4-photoproducts. (A), Cells were irradiated by UV and 6–4-photoproducts were detected as described at 0 and 7 h. NER activity is expressed by the percent of 6–4-photoproducts removed by 7 h after UV irradiation. The H460 cell line and its engineered, ERCC4 deficient derivative was used as positive and negative controls. (B), On the barplot the mean of the measurements is shown 7 h after the UV irradiation, normalized by the signal at measured at 0 h. The two whiskers represent the mean plus and minus the standard error.
