Table 1 DAPs involved in the metabolism of IPEC-J2 cells exposed to n-3 PUFA, LPS, or n-3 PUFA + LPS treatments (log₂FC ≥ 1.2 or ≤ -1.2 with adjusted p-value ≤ 0.05).

From: Comprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes

Protein ID	Protein description	Gene name	n-3 PUFA versus Ctrl (log₂FC)	LPS versus Ctrl (log₂FC)	n-3 PUFA + LPS versus Ctrl (log₂FC)
Q079S8	Nucleotide binding protein like	NUBPL	− 4.23	0	0
A0A4X1SLV1	Diphosphomevalonate decarboxylase	MVD	− 2.69	0	− 2.6
P00503	Phosphoglucomutase 1	PGM1	− 1.47	0	0
F1RQM4	3-hydroxyacyl-[acyl-carrier-protein] dehydratase	FASN	− 1.28	0	0
A0A4X1T7V5	L-lactate dehydrogenase	LDHA	− 1	− 1.22	0
P50578	Sterol-C5-desaturase	SC5D	0	0	− 3.39
A0A4X1SH01	Caveolin 1	CAV1	0	0	− 3.28
F6QAM9	Choline transporter-like protein 2 isoform X1	SLC44A2	0	0	− 2.67
A0A5G2QES7	5-oxoprolinase, ATP hydrolysing	OPLAH	0	0	− 2.49
A0A4X1SLI2	Peptidyl-prolyl cis–trans isomerase	PPIL3	0	0	− 2.47
A0A288CFT0	Cytochrome b5 heme-binding domain-containing protein	FADS2	0	0	− 2.4
A8U4R4	NADH-ubiquinone oxidoreductase chain 1	ND1	0	− 5.06	− 2.31
A0A481C945	Fatty acid desaturase 1a	FADS1	0	0	− 2.13
A0A4X1T629	Thioredoxin domain-containing protein	TXN2	0	0	− 2.01
A0A287BDT8	Stearoyl-CoA desaturase	SCD	0	0	− 1.9
A0A4X1W2X5	Butyryl-CoA dehydrogenase	IVD	0	0	− 1.71
F1RPH0	Exostosin 1	EXT1	0	0	− 1.63
A0A480QDJ5	Hexosyltransferase	B3GALT5	0	0	− 1.61
A0A4X1TT31	Transducin Beta-Like Protein 1X	TBL1X	0	0	− 1.6
A0A5K1UCS8	Acyl-CoA-binding protein	DBI	0	− 3.57	− 1.47
A0A4X1V8G3	Cytochrome c oxidase subunit	COX6B	0	− 1.1	− 1.42
A0A287A8M1	NADH ubiquinone oxidoreductase 9 kDa subunit	NDUFV3	0	0	− 1.42
P00355	NAD(P)H-hydrate epimerase	NAXE	0	0	− 1.22
A0A287A1Y5	Aspartate aminotransferase, cytoplasmic	GOT1	0	− 3.22	0
F1SUE3	Malic enzyme	ME1	0	− 2.77	0
A0A4X1TEA2	Glutathione synthetase	GSS	0	− 2.49	0
A0A4X1TPV9	Aldo–keto reductase family 1 member A1	AKR1A1	0	− 2.18	0
A0A481CLJ7	S-formylglutathione hydrolase	ESD	0	− 2.11	0
A0A480X8T8	Adenylosuccinate lyase	ADSL	0	− 1.95	0
A0A287A808	S-(hydroxymethyl)glutathione dehydrogenase	ADH5	0	− 1.91	0
A0A0B8RVZ5	Leukotriene A(4) hydrolase	LTA4H	0	− 1.74	0
A0A287AA47	Triosephosphate isomerase	TPI1	0	− 1.7	0
A0A287AWS9	Transketolase	TKT	0	− 1.7	0
A0A287BQP2	Farnesyl pyrophosphate synthase isoform a	FDPS	0	− 1.66	0
A0A480TFA5	Thioredoxin-disulfide reductase	TXNRD1	0	− 1.66	0
A0A480UCJ4	Phosphoglycolate phosphatase	PGP	0	− 1.62	0
A0A480VNV2	Acyl-CoA Thioesterase 7	ACOT7	0	− 1.59	0
A0A4X1T9M8	Phosphoglycerate kinase	PGK1	0	− 1.56	0
A0A4X1TYP2	28S ribosomal protein S15, mitochondrial	MRPS15	0	− 1.49	0
A0A4X1TZ03	ML domain-containing protein	GM2A	0	− 1.47	0
A0A4X1U393	3-hydroxy-3-methylglutaryl coenzyme A synthase	HMGCS1	0	− 1.46	0
A0A4X1U9G6	UDP-glucose ceramide glucosyltransferase	UGCG	0	− 1.45	0
A0A4X1UTQ9	Isocitrate dehydrogenase [NADP]	IDH1	0	− 1.43	0
A0A4X1VLC0	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0	− 1.43	0
A0A4X1VNK1	Mediator of RNA polymerase II transcription subunit 16	MED16	0	− 1.42	0
A0A4X1VYI7	Inorganic diphosphatase	PPA1	0	− 1.42	0
A0A4X1VYQ8	Adenine phosphoribosyltransferase	APRT	0	− 1.41	0
A0A4X1W580	Fructose-bisphosphate aldolase	ALDOC	0	− 1.4	0
A0A4X1WBQ4	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	ADI1	0	− 1.39	0
A0A5G2QAF0	BTB Domain And CNC Homolog 1	BACH1	0	0	1.27
A0A5G2QNU5	Cytidine deaminase	CDA	0	0	1.34
A0A5G2QPA8	Carnitine O-palmitoyltransferase 1A	CPT1A	0	0	1.48
A0A5G2R8S6	Fatty acyl-CoA reductase	FAR1	0	0	1.59
D2D0E3	Patatin Like Phospholipase Domain Containing 2	PNPLA2	0	0	1.62
F2Z5T7	Perilipin 3	PLIN3	0	0	1.71
Q5BLZ2	Glutamate-cysteine ligase modifier subunit	GCLM	0	0	2
U5HTD3	1-acylglycerol-3-phosphate O-acyltransferase	ABHD5	0	0	2.14
A0A1L1YNR3	Heme oxygenase 1	HMOX1	0	0	3.24
A0A287B0C7	Hydrolase_4 domain-containing protein	MGLL	1.25	0	1.43
A0A4X1T8J4	Epoxide hydrolase 1	EPHX1	2.81	0	0
G0Z3A1	Perilipin 2	PLIN2	5.09	0	5.74

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Table 1 DAPs involved in the metabolism of IPEC-J2 cells exposed to n-3 PUFA, LPS, or n-3 PUFA + LPS treatments (log₂FC ≥ 1.2 or ≤ -1.2 with adjusted p-value ≤ 0.05).

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