Figure 4

Comparison of oncogenic pathway activity between PANoptosis High versus PANoptosis Low tumors (bulk RNA-Seq) for LGG, KIRC and SKCM. (A) Pearson correlation coefficient between the PANoptosis activity and enrichment scores of the 54 oncogenic pathways²³ for each of the three cancer types. The correlation co-efficient (R) was considered significant if |R|> 0.25 with ***P-value < 1e−5. (B) Heatmap of the average activation across bulk RNA-Seq tumor profiles for the oncogenic pathway estimated using ssGSEA for PANoptosis High and Low clusters for LGG, KIRC and SKCM cancers. The difference in average activity of oncogenic pathways between PANoptosis High versus PANoptosis Low groups was highlighted as ∆Activity and the significance in difference was estimated using a Wilcoxon rank-sum test with *P-value ∈ (1e−2, 0.5*1e−2]; **P-value ∈ (1e−3, 1e−2]; ***P-value < 1e−3. Samples from the PANoptosis High group are depicted below the red bar and samples from the PANoptosis Low group are depicted below the blue bar.