Figure 6 | Scientific Reports

Figure 6

From: Comparative analysis identifies genetic and molecular factors associated with prognostic clusters of PANoptosis in glioma, kidney and melanoma cancer

Figure 6

Single-cell analysis reveals oncogenic pathways correlated with PANoptosis score across immune, stromal and cancer cells in melanoma dataset. (A) UMAP plot highlighting the different cell type composition of the melanoma single cell transcriptomic dataset. (B) Pearson correlation between PANoptosis score and activity scores of the 54 oncogenic pathways across the immune, stroma and cancer cell types in the scRNA-Seq dataset. The correlation coefficients (R) were considered significant if |R|> 0.25 with *P-value ∈ (1e−3, 0.5*1e−2]; **P-value ∈ (1e−5, 1e−3]; ***P-value < 1e−5. Heatmap of the pathway activities determined using ‘enrichIt’ function for the different immune, cancer and stroma cell types and its comparison with the PANoptosis scores is shown.

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