Table 3 Assessment of the certainty of evidence presented for each outcome.

From: Effects of therapeutic exercise on the motor function of adults with Down syndrome: a systematic review and meta-analysis

Evaluation of certainty

Summary of outcomes

No. of studies

Study design

Risk of bias

Inconsistency

Indirect evidence

Imprecision

Other considerations

No. of patients

Effect

Certainty

Therapeutic exercise

Control

Relative (95% CI)

Absolute (95% CI)

Aerobic exercise. Muscular strength – Sit-to-stand test (monitoring range 6–12 weeks; assessed with Number of repetitions)

 2

RCT1,5

not seriousa

not serious

not serious

seriousb

none

26

29

SMD 0.15 higher

(− 0.48;1.27)

Moderate

Combined exercise. Muscular strength—1 RM Leg press (monitoring range 10–12 weeks; assessed with Weight Lifted)

 2

RCT8,16

Seriousc

not serious

not serious

seriousb

none

39

33

SMD 0.56 higher

(0.08;1.04)

Low

Combined exercise. Muscular strength—1 RM chest press (monitoring range 10–12 weeks; assessed with Weight lifted)

 2

RCT8,16

Seriousc

not serious

not serious

seriousb

none

39

33

SMD 0.73 higher

(0.25;1.22)

Low

Balance

 4

RCT1,10,29,32

Seriousa

not serious

not serious

seriousb

none

54

47

Carmeli et al10 with aerobic exercise reported significant improvements in dynamic balance between groups p < 0.05. Cai et al.29 with a combined exercise plan showed significant increase of dynamic and static balance

Low

Aerobic exercise. Gait

 1

RCT13

Seriousa

not serious

not serious

not serious

none

11

11

Skiba et al. found an improvement in the space–time parameters, angular changes of the limbs, and mean values of the angular deviations at the joints

Moderate

Combined exercise. Functional Fitness—6 min walking distance (6MWD) (monitoring 14 weeks)

 1

RCT28

Seriousa

not serious

not serious

Not seriousa

none

6

6

Perrot et al. showed significant improvements in functional task using combined exercise via nintendo wii

Moderate

  1. RCT Randomized clinical trial.
  2. aUnclear risk of bias in masking.
  3. bWide confidence intervals that pass the line of no effect.
  4. cUnclear risk of bias in 4 of 7 criteria.