Table 1 Characteristics of study participants.

From: Integrated omics analysis of coronary artery calcifications and myocardial infarction: the Framingham Heart Study

Characteristic/analysis

Total (n = 3106)

All analyses*

3106

 GWAS, n (%)

2932 (94.4%)

 Gene expression, n (%)

2729 (87.9%)

 DNA methylation, n (%)

1936 (62.3%)

Age, mean (SD)

57 ± 10

Sex (women), n (%)

1519 (48.9%)

Obese (BMI above 30), n (%)

993 (32.0%)

Diabetes, n (%)

251 (8.1%)

Smoking, n (%)

244 (7.9%)

Hypercholesterolemia, n (%)

975 (31.4%)

Hypertension, n (%)

1289 (41.5%)

Prevalent CAC, n (%)

1403 (45.2%)

Continuous CAC, median IQR

67.8 (10.8, 274.9)

Prevalent MI, n (%)

65 (2.1%)

Incident MI, n (%)

60 (1.9%)

  1. All comorbidities are measured at baseline, i.e. the time of the Framingham Heart Study examination.
  2. BMI body mass index, MI myocardial infarction, CAC coronary artery calcification.
  3. *In our study population, 2589 (83.4%) had data on both GWAS and gene expression, 1842 (59.3%) had data on both GWAS and DNA methylation, 1690 (54.4%) had data on both gene expression and DNA methylation, and 1614 (52.0%) had all data on all three omics.
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