Figure 1
(a) A monolithic quartz contact guidance platform (left) and a schematic diagram of how cell topography is characterized on the micropatterned substrate (right). A–A is a cross sectional view of the platform showing groove (Gw) and ridge (Rw) widths, and groove depth (GD). The outline of a cell is fitted by an ellipse to estimate a length ratio of the major to minor axes and a cell alignment angle (\(\uptheta\)) between the major axis and the direction of the groove patterns. (b) Optical images of live Hs27 cells on \({{\text{G}}}_{{\text{w}}}={{\text{R}}}_{{\text{w}}}=10\,\upmu\)m (i.e., G10R10) with (left) \({{\text{G}}}_{{\text{D}}}=\) 330 nm, (middle) = 725 nm, and (right) = 1000 nm, respectively.
