Figure 2

Immunohistochemical detection of MUC6-, αGlcNAc-, and TFF2-positive cells in high-grade PGA. The inset shows an enlarged view of a H&E section. H&E staining shows loss of cell polarity and evident nucleolus, indicating high grade PGA lesion (case No.4 in Supplementary Table 1). Immunohistochemistry against MUC6 antibodies indicates broad positivity. By contrast, αGlcNAc, and TFF2 staining is reduced relative to that of MUC6. Scale bar: 100 µm. Inset scale bar: 10 µm.