Table 2 Effects of inflammatory cytokines on bacteriophage of weanling piglets challenged with Bordetella bronchiseptica (BBC).

Treatment¹	NC	Challenge (Bordetella bronchiseptica)				SEM²	p-value
Treatment¹	NC	PC	BF	BN	AT	SEM²	p-value
Phase 1 (d 7)
IL-1β	25.1^d	139.0^a	121.1^b	104.6^c	93.3^c	3.82	< 0.001
IL-6	127.6^e	323.8^a	252.6^b	199.3^c	161.0^d	8.32	< 0.001
TNF-α	189.4^d	289.7^a	230.8^b	220.5^bc	210.1^c	8.79	< 0.001
Phase 2 (d 14)
IL-1β	37.8^d	190.3^a	113.3^b	97.7^c	88.7^c	4.09	< 0.001
IL-6	117.4^e	303.1^a	224.3^b	179.8^c	141.2^d	8.44	< 0.001
TNF-α	251.4^c	324.2^a	287.9^b	257.7^c	241.8^c	10.9	< 0.001

¹NC, control group; PC, with BBC; BF, bacteriophage in feed (10⁸ pfu /kg diet) + BBC; BN, bacteriophage nasal spray (2 × 10⁷ pfu) + BBC; AT, 1 g florfenicol/kg + BBC.
²SEM, standard error of means.
^a–dmeans with different superscripts in the same row differ significantly(p < 0.05).

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