Figure 5

Distribution of brain age gap by clinical diagnosis. The mean (SD) brain age gaps were 0.413 (3.515) years and 1.393 (3.606) years for the MCI and AD groups, respectively. A significant difference in brain age gaps between the MCI and AD group was identified (t = − 2.673, P = 0.008). Abbreviations: AD, Alzheimer's disease; MCI, mild cognitive impairment; SD, standard deviation.