Figure 5 | Scientific Reports

Figure 5

From: A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma

Figure 5

The construction and validation of the clinical risk prognostic model. (A) Ten-fold cross-validation for tuning parameter selection in the LASSO model. (B) LASSO coefficient profiles of the CIC-related TFs with prognostic value. (C) The coefficients of selected genes. Red represented coefficient > 0, and blue represented coefficient < 0. (D) Kaplan–Meier curve plot of overall survival for patients from the TARGET cohort. (E) The 1-, 3- and 5- year ROC plots for the TARGET cohort. (F–H) Distributions of risk score, survival status, and RNA expression profile of selected TFs in TARGET cohort. (I) Kaplan–Meier curve plot of overall survival for patients from the GSE21257 cohort. (J) The 1-, 3-, 5- year ROC plots for the GSE21257 cohort. (K-M) Distributions of risk score, survival status, and RNA expression profile of selected TFs in the GSE21257. The color in heatmaps (H & M) represents the relative RNA expression.

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