Figure 2 | Scientific Reports

Figure 2

From: High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker

Figure 2

Trop2 can be detected in urine from clinically significant prostate cancer patients. (A) Schematic representation of experimental design (generated via BioRender (https://biorender.com). (B) Trop2 levels were assessed by ELISA in urine from cancer-free patients (n = 40) and prostate cancer patients (n = 39). p = 0.0285, determined by Student-T test (Two-tailed). (C) Trop2 levels in urine samples from patients with clinically significant prostate cancer were evaluated by ELISA (20ul/sample) or Western blot (30 μl urine/sample). For Western Blot, 10 patients were run in the same gel with positive control, and two blots were developed at the same time with the same exposure time. (D) The correlation of Trop2 levels from ELISA and WB analysis. P = 0.0065. (E) Trop2 levels in patient-matched tissues were evaluated by IHC staining. Scale bar = 25 microns.

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