Table 4 The performance of the 11 gene pairs’ signature in independent datasets.
From: Development of machine learning-based predictors for early diagnosis of hepatocellular carcinoma
Dataset | NO.HCC | NO.CwoHCC | mRMR + KNN | mRMR + SVM | MRMD + SVM | |||
|---|---|---|---|---|---|---|---|---|
Sn | Sp | Sn | Sp | Sn | Sp | |||
Testing set (biopsy) | 29 | 48 | 1 | 1 | 1 | 1 | 1 | 0.8542 |
Testing set (surgery) | 220 | 36 | 1 | 1 | 1 | 1 | 1 | 0.8889 |
GEO (biopsy) | ||||||||
 GSE121248 | 70 | – | 0.9286 | – | 0.9429 | – | 1 | – |
 GSE47197 | 61 | – | 0.3607 | – | 0.9836 | – | 1 | – |
GEO (surgery) | ||||||||
 GSE109211 | 140 | – | 0.7214 | – | 0.7786 | – | 0.9929 | – |
 GSE62743 | 132 | – | 0.6288 | – | 0.8636 | – | 1 | – |
 GSE46444 | 88 | – | 0.3409 | – | 0.5227 | – | 1 | – |
 GSE10141 | 80 | – | 0 | – | 0.9875 | – | 1 | – |
 GSE164760 | 53 | – | 0.0755 | – | 0.2453 | – | 1 | – |
 GSE19977 | 164 | – | 1 | – | 0.9939 | – | 1 | – |
 GSE112790 | 183 | – | 0.9836 | – | 0.9945 | – | 1 | – |
 GSE102079 | 152 | – | 0.9737 | – | 0.9934 | – | 1 | – |
 GSE76427 | 115 | – | 0.7826 | – | 0.9478 | – | 1 | – |
 GSE78737 | 103 | – | 0.2427 | – | 0.3301 | – | 0.8544 | – |
 GSE9843 | 91 | – | 0.9231 | – | 0.9231 | – | 1 | – |
 GSE43619 | 88 | – | 0.7273 | – | 0.8523 | – | 1 | – |
 GSE62232 | 81 | – | 0.9506 | – | 0.9753 | – | 1 | – |
 GSE39791 | 72 | – | 1 | – | 1 | – | 1 | – |
 GSE15765 | 70 | – | 0.9571 | – | 1 | – | 1 | – |
 GSE87630 | 64 | – | 0 | – | 1 | – | 1 | – |
 GSE36411 | 42 | – | 0.8095 | – | 0.881 | – | 1 | – |
 GSE89377 | 40 | – | 0 | – | 0.2 | – | 0.825 | – |
 GSE57957 | 39 | – | 1 | – | 0.9744 | – | 1 | – |
 GSE14323 | 38 | – | 0.0789 | – | 0.1579 | – | 0.5263 | – |
 GSE6764 | 35 | – | 0.8 | – | 0.8286 | – | 1 | – |
 GSE101685 | 24 | – | 1 | – | 1 | – | 1 | – |
 GSE84598 | 22 | – | 1 | – | 1 | – | 1 | – |
 GSE41804 | 20 | – | 0.9 | – | 1 | – | 1 | – |
 GSE17548 | 17 | – | 0.7059 | – | 0.7059 | – | 1 | – |
 GSE84402 | 13 | – | 0 | – | 0.0769 | – | 1 | – |
 GSE115018 | 12 | – | 0 | – | 0.9167 | – | 1 | – |
 GSE98383 | 11 | – | 0.9091 | – | 1 | – | 1 | – |
 GSE29721 | 10 | – | 0.8 | – | 0.8 | – | 1 | – |
 GSE116174 | 64 | – | 0.9063 | – | 1 | – | 1 | – |
ICGC (surgery) | 243 | – | – | – | – | – | – | – |
TCGA (surgery) | 371 | – | – | – | – | – | – | – |
