Table 4 Multivariate analysis predicting the risk of mortality with aortic calcification and higher galectin levels (≥ 37.0 ng/mL).

From: Mediating effect of vascular calcification in galectin-3-related mortality in hemodialysis patients

 

All-cause mortality

Univariate analysis

Multivariate analysis*

HR (95% CI)

p

HR (95% CI)

p

Age

1.07 (1.05–1.09)

< 0.001

1.05 (1.02–1.07)

0.001

Sex, male

0.92 (0.66–1.28)

0.626

–

–

CVC use

3.26 (2.30–4.61)

< 0.001

3.27 (1.78–6.03)

< 0.001

CAD, history

1.60 (1.13–2.27)

0.008

0.73 (0.40–1.33)

0.301

Diabetes

1.03 (0.74–1.45)

0.860

–

–

Albumin < 3.5 g/dL

1.60 (1.14–2.24)

0.006

1.13 (0.67–1.89)

0.652

Phosphate ≥ 5.0 mg/dL

0.74 (0.53–1.03)

0.101

–

–

hsCRP ≥ 1.0 mg/L

2.32 (1.48–3.65)

< 0.001

1.49 (1.02–2.59)

0.046

HDL-C mg/dL

0.98 (0.97–0.99)

0.032

1.00 (0.98–1.02)

0.704

BNP ≥ 1200 mmol/L

1.67 (1.14–2.44)

0.008

1.27 (0.72–2.26)

0.410

Galectin-3 ≥ 37 ng/mL

3.08 (2.20–4.32)

< 0.001

1.71 (1.02–2.92)

0.048

AoAC

 0

Reference

 

Reference

 

 1

1.34 (0.83–2.16)

0.227

1.34 (0.65–2.78)

0.434

 2

2.37 (1.51–3.73)

< 0.001

1.81 (0.92–3.91)

0.127

 3

7.48 (4.81–11.62)

< 0.001

1.98 (1.01–4.00)

0.049

  1. CVC central venous catheter, CAD coronary artery disease, HDL high density lipoprotein, hsCRP high-sensitivity C-reactive protein, BNP brain-natriuretic peptide, AoAC aortic arch calcification.
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