Figure 4

Relative importance of SES–DEG and upstream regulators to the immune dysregulation. The figure shows the upstream regulators along with the SES–DEG represented as layers (4 in total). The innermost layer represents genes and upstream regulators that are involved in the enrichment of more than 10 functional pathways (in Fig. 3) and thus they are pivotal in immune dysregulation, whereas the outermost layer consists of genes and upstream regulators that are only involved in 1 enriched biological process.