Table 5 Pro Tox II toxicity prediction of toxicity points and receptors for Chamanetin.
Classification | Target | Prediction | Probability |
|---|---|---|---|
Organ toxicity | Hepatotoxicity | Inactive | 0.72 |
Toxicity endpoints | Carcinogenicity | Inactive | 0.71 |
Toxicity endpoints | Immunotoxicity | Inactive | 0.72 |
Toxicity endpoints | Mutagenicity | Inactive | 0.68 |
Toxicity endpoints | Cytotoxicity | Inactive | 0.68 |
Tox21-nuclear receptor signaling pathways | Aryl hydrocarbon receptor (AhR) | Inactive | 0.64 |
Tox21-nuclear receptor signaling pathways | Androgen receptor (AR) | Inactive | 0.76 |
Tox21-nuclear receptor signaling pathways | Androgen receptor ligand binding domain (AR-LBD) | Inactive | 0.99 |
Tox21-nuclear receptor signalling pathways | Aromatase | Inactive | 0.75 |
Tox21-Nuclear receptor signalling pathways | Estrogen receptor alpha (ER) | Active | 0.69 |
Tox21-nuclear receptor signalling pathways | Estrogen receptor ligand binding domain (ER-LBD) | Active | 0.5 |
Tox21-nuclear receptor signalling pathways | Peroxisome proliferator activated receptor gamma (PPAR-Gamma) | Inactive | 0.69 |
Tox21-stress response pathways | Nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE) | Inactive | 0.93 |
Tox21-stress response pathways | Heat shock factor response element (HSE) | Inactive | 0.93 |
Tox21-stress response pathways | Mitochondrial membrane potential (MMP) | Active | 0.72 |
Tox21-stress response pathways | Phosphoprotein (tumor supressor) p53 | Inactive | 0.54 |
Tox21-stress response pathways | ATPase family AAA domain-containing protein 5 (ATAD5) | Inactive | 0.78 |
