Table 4 Univariable and multivariable Cox analyses on variables for the prediction of cancer-specific survival of intrahepatic cholangiocarcinoma patients. HR hazard ratio, CI confidence interval, *P < 0.05, **P < 0.01, ***P < 0.001.

From: Development and validation of web-based nomograms for predicting survival status in patients with intrahepatic cholangiocarcinoma depending on the surgical status: a SEER database analysis

Variables

Univariable Cox analysis

Multivariable Cox analysis

HR (95% CI)

P value

HR (95% CI)

P value

Age

 < 50

Reference

 

Reference

 

 50–64

1.212 (0.945–1.533)

0.129

1.210 (0.943–1.553)

0.135

 65–79

1.255 (0.983–1.602)

0.068

1.335 (1.044–1.708)

0.022*

 ≥ 80

1.836 (1.307–2.578)

< 0.001***

2.159 (1.527–3.052)

< 0.001***

Sex

 Female

Reference

Reference

 

 Male

1.190 (1.024–1.383)

0.024*

1.179 (1.011–1.374)

0.035*

Race

 White

Reference

  

 Black

1.058 (0.805–1.391)

0.685

  

 Other

0.930 (0.750–1.155)

0.512

  

AJCC T stage

 T1

Reference

Reference

 

 T2

1.717 (1.427–2.064)

< 0.001***

1.400 (1.155–1.696)

< 0.001***

 T3

2.052 (1.631–2.582)

< 0.001***

1.837 (1.450–2.327)

< 0.001***

 T4

1.822 (1.350–2.459)

< 0.001***

1.917 (1.417–2.595)

< 0.001***

AJCC N stage

 N0

Reference

Reference

 

 N1

1.940 (1.659–2.268)

< 0.001***

1.324 (1.122–1.563)

< 0.001***

AJCC M stage

 M0

Reference

Reference

 

 M1

2.840 (2.406–3.353)

< 0.001***

1.520 (1.259–1.833)

< 0.001***

Grade

 I

Reference

Reference

 

 II

1.191 (0.900–1.576)

0.222

1.152 (0.868–1.527)

0.328

 III + IV

1.834 (1.389–2.421)

< 0.001***

1.621 (1.223–2.149)

< 0.001***

Tumor size

 ≤ 5 cm

Reference

Reference

 

 > 5 cm

1.595 (1.354–1.880)

< 0.001***

1.094 (0.920–1.300)

0.310

Surgery

 No

Reference

Reference

 

 Yes

0.284 (0.242–0.334)

< 0.001***

0.373 (0.311–0.449)

< 0.001***

Chemotherapy

 No

Reference

 

 Yes

1.040 (0.889–1.217)

0.622

  

Radiotherapy

 No

Reference

 

 Yes

0.904 (0.741–1.104)

0.322

  
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