Table 1 Characteristics of the study population (n = 394).

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

Variable

All (n = 394)

Women (n = 235, 60%)

Men (n = 159, 40%)

Age, years, mean (SD)

48.9 (13.8)

48.5 (13.7)

49.5 (13.9)

Height, cm, mean (SD)

171 (9.4)

166 (7.2)

178 (7.2)

BMI, kg/m2, mean (SD)

26.0 (5.0)

25.2 (4.8)

27.2 (4.9)

Fasting at blood collection (≥ 6 h), n %)

48 (12.2)

23 (9.8)

25 (15.7)

Self-reported osteoporosis diagnosis, n (%)

13 (3.3)

11 (4.7)

2 (1.3)

Self-reported diabetes diagnosis, n (%)

19 (4.8)

10 (4.3)

9 (5.7)

Self-reported autoimmune disease diagnosis, n (%)

9 (2.3)

8 (3.4)

1 (0.6)

Self-reported inflammatory bowel disease diagnosis, n (%)

5 (1.3)

4 (1.7)

1 (0.6)

PAPP-A2, ng/mL, median (P25, P75)

0.25 (0.19, 0.33)

0.26 (0.20, 0.33)

0.24 (0.18, 0.32)

PAPP-A, ng/mL (values above detection limit), median (P25, P75)

6.6 (4.8, 9.9)

5.9 (4.5, 8.5)

7.7 (5.4, 10.4)

PAPP-A, ng/mL (values below detection limit substituted), median (P25, P75)

5.1 (1.5, 8.2)

4.6 (1.5, 6.9)

6.5 (3.8, 9.9)

Stanniocalcin-2, ng/mL, median (P25, P75)

87.6 (72.8, 102.9)

86.7 (70.8, 103.4)

88.2 (74.7, 102.9)

Total IGF-1, ng/mL, median (P25, P75)

177.4 (138.4, 227.6)

168.8 (131.8, 214.8)

188.6 (145.7, 244.9)

free IGF-1, ng/mL, median (P25, P75)

1.02 (0.38, 2.07)

1.20 (0.48, 2.31)

0.78 (0.28, 1.71)

IGFBP-1, ng/mL, median (P25, P75)

1.98 (0.90, 3.90)

2.59 (1.19, 4.80)

1.39 (0.61, 2.75)

IGFBP-2, ng/mL, median (P25, P75)

302.0 (201.6, 437.0)

321.5 (203.9, 451.0)

282.4 (197.3, 406.1)

IGFBP-3, ng/mL, median (P25, P75)

3579 (3177, 3965)

3630 (3295, 4036)

3497 (3063, 3870)

IGFBP-5, ng/mL, median (P25, P75)

22.6 (6.2, 73.7)

21.3 (4.5, 65.2)

23.6 (7.9, 85.2)

free to total IGF-1 ratio, %, median (P25, P75)

0.54 (0.24, 1.13)

0.65 (0.30, 1.20)

0.42 (0.17, 0.88)

IGF1/IGFBP-3 molar ratio, %, median (P25, P75)

17.8 (14.4, 22.3)

16.8 (13.5, 20.6)

19.6 (16.3, 24.0)

  1. N = 394, except for results on free IGF-1 (n = 339), IGFBP-1 (n = 360), IGFBP-5 (n = 125), and PAPP-A above detection limit (N = 288).
  2. BMI body mass index, PAPP-A pregnancy-associated plasma protein A, PAPP-A2 pregnancy-associated plasma protein A2, STC2 stanniocalcin 2, SD standard deviation.
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