Table 2 Pearson partial correlation coefficients ofPAPP-A, PAPP-A2 and STC with IGF-1, and IGF-binding proteins*.

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

 

Age

Total IGF-1

Free IGF-1†

IGFBP-1†

IGFBP-2

IGFBP-3

IGFBP-5†

Free to total IGF-1 ratio†

IGF-1/IGFBP3 molar ratio

Age

 

− 0.42

− 0.20

0.005

0.16

− 0.25

− 0.08

− 0.10

− 0.33

(p < 0.001)

(p < 0.001)

(p = 0.93)

(p = 0.002)

(p < 0.001)

(p = 0.39)

(p = 0.06)

(p < 0.001)

PAPP-A† (values above detection limit)

− 0.04

0.09

0.10

0.06

0.03

− 0.04

0.30

0.08

0.12

(p = 0.45)

(p = 0.12)

(p = 0.12)

(p = 0.32)

(p = 0.61)

(p = 0.52)

(p = 0.004)

(p = 0.21)

(p = 0.04)

PAPP-A† (values below detection limit substituted)

0.03

0.06

0.08

0.04

0.10

− 0.02

0.30

0.07

0.07

(p = 0.56)

(p = 0.24)

(p = 0.13)

(p = 0.43)

(p = 0.06)

(p = 0.76)

(p = 0.0009)

(p = 0.18)

(p = 0.16)

PAPP-A2

0.19

− 0.16

0.005

0.07

0.17

− 0.10

− 0.03

0.06

− 0.13

(p < 0.001)

(p = 0.002)

(p = 0.93)

(p = 0.16)

(p < 0.001)

(p < 0.05)

(p = 0.78)

(p = 0.31)

(p = 0.008)

Stanniocalcin-2

− 0.21

− 0.12

0.04

0.18

− 0.16

− 0.11

− 0.05

0.07

− 0.06

(p < 0.001)

(p = 0.02)

( p = 0.41)

(p = 0.0005)

(p = 0.0016)

(p = 0.03)

(p = 0.56)

(p = 0.18)

(p = 0.24)

  1. N = 394, except for results on IGFBP-1 (n = 360), IGFBP-5 (n = 125), free IGF-1 (N = 339) and PAPP-A above detection limit (N = 288).
  2. *Correlations between biomarkers were adjusted for age, sex, BMI, and pretest; correlations with age were adjusted for sex.
  3. †IGFBP-1, IGFBP-5, free IGF-1, free-to-total IGF-1 ratio and PAPP-A were log-transformed for analysis.
  4. Significant values are in bold.
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