Table 3 Multivariable adjusted* plasma concentrations of IGF-1 and IGF-binding protein concentrations by categories of PAPP-A concentrations.

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

 

PAPP-A

P-trend

β (95% CI) per log-transformed PAPP-A (values above detection limit)§

β (95% CI) per log-transformed PAPP-A (values below detection limit substituted))§

Below detection limit

Quartile 1

Quartile 2

Quartile 3

Quartile 4

IGF-1, ng/ml†

185.7

177.3

201.9

185.2

185.5

 

7.8

4.3

(172.8, 198.6)

(162.6, 192.0)

(187.8, 216.1)

(170.8, 199.6)

(171.1, 200.0)

0.99

(− 2.0, 17.7)

(− 2.7, 11.2)

Free IGF1ठ(values above detection limit)

0.80

0.83

0.97

0.67

1.08

 

1.20

1.12

(0.58, 1.10)

(0.58, 1.18)

(0.69, 1.36)

(0.47, 0.96)

(0.77, 1.53)

0.24

(0.95, 1.51)

(0.96, 1.32)

IGFBP-1, ng/mL‡║§

2.00

1.61

2

2.26

2.28

 

1.12

1.06

(1.54, 2.59)

(1.22, 2.12)

(1.53, 2.63)

(1.72, 2.96)

(1.73, 3.01)

0.16

(0.94, 1.32

(0.94, 1.19)

IGFBP-2, ng/mL†

302.6

321.3

319.4

338.2

384.1

 

6.7

16.6

(270.1, 335.1)

(284.3, 358.3)

(283.8, 355.0)

(302.0, 374.4)

(347.8, 420.5)

0.001

(− 19.2, 32.7)

(− 0.9, 34.1)

IGFBP-3, ng/mL†

3537

3558

3707

3523

3464

 

− 32.0

− 9.2

(3398, 3676)

(3400, 3717)

(3555, 3860)

(3368, 3678)

(3308, 3619)

0.28

(− 139.2, 75.2)

(− 83.6, 65.2)

IGFBP-5, ng/mL‡§

13.1

18.1

17.3

36.0

33.1

 

1.97

1.69

(7.1, 24.3)

(7.8, 42.4)

(8.4, 35.7)

(17.8, 72.8)

(17.0, 64.2)

0.02

(1.26, 3.12)

(1.25, 2.29)

IGF-1/IGFBP-3 molar ratio, %†

19.0

18.0

19.9

19.0

19.4

 

0.92

0.44

(17.9, 20.2)

(16.6, 19.3)

(18.7, 21.2)

(17.6, 20.3)

(18.1, 20.7)

0.54

(0.02, 1.82)

(− 0.19, 1.07)

Free to total IGF-1 ratio, %‡§

0.43

0.49

0.49

0.36

0.60

 

1.15

1.10

(0.32, 0.59)

(0.35, 0.69)

(0.35, 0.69)

(0.26, 0.51)

(0.43, 0.84)

0.23

(0.92, 1.45)

(0.94, 1.29)

PAPP-A2, ng/mL†

0.27

0.27

0.27

0.28

0.28

 

0.01

0.01

(0.24, 0.29)

(0.24, 0.29)

(0.25, 0.30)

(0.25, 0.30)

(0.25, 0.31)

0.25

(− 0.01, 0.03)

(− 0.01, 0.02)

Stanniocalcin-2, ng/mL† 

92.3

88.7

85.7

80.7

82.0

 

− 2.5

− 4.0

(86.6, 98.05)

(82.2, 95.3)

(79.4, 92.0)

(74.3, 87.1)

(75.6, 88.4)

0.01

(− 6.3, 1.0)

(− 7.1, − 0.9)

  1. N = 394, except for results on free IGF-1 (N = 339), IGFBP-1 (N = 360), IGFBP-5 (N = 125), and PAPP-A above detection limit (N = 288).
  2. *Adjusted for age, sex, BMI, and pretest.
  3. †Results for IGF-1, IGFBP-2, IGFBP-3, IGF-1/IGFBP-3 molar ratio, PAPP-A2 and stanniocalcin-2 are means (95%-confidence intervals).
  4. ‡Results for IGFBP-1, IGFBP-5, free IGF-1 and free to total IGF-1 ratio are geometric means (95%-confidence intervals).
  5. ║Models for IGFBP-1 were additionally adjusted for fasting status (≥ 6 h, yes vs no).
  6. §For IGFBP-1, IGFBP-5, free IGF-1, and free to total IGF-1 ratio  β estimates per log-transformed PAPP-A increment were back-transformed from the logarithmic to the original scale; back transformed estimates can be interpreted as x-fold IGFBP-1 or IGFBP-5 or free IGF-1 concentrations or free to total IGF-1 ratio associated with one unit higher log-transformed PAPP-A.
  7. Significant values are in bold.
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