Table 4 Association of PAPP-A with IGFBP-5 with additional adjustment for IGF-1 or other IGFBPs.

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

 

n

β per log-transformed PAPP-A (values above detection limit)

95% CI

β per log-transformed PAPP-A (values below detection limit substituted))

95% CI

IGFBP-5, ng/mL‡

As in Table 3

125

1.97

(1.26, 3.12)

1.69

 (1.25, 2.29)

- Plus adjustment for IGF-1

125

1.98

(1.27, 3.10)

1.68

(1.24, 2.26)

- Plus adjustment for IGFBP-2

125

1.97

(1.25, 3.11)

1.66

(1.23, 2.26)

- Plus adjustment for IGFBP-3

125

1.99

(1.26, 3.15)

1.71

(1.26, 2.32)

In participants with available IGFBP-1

116

2.08

(1.31, 3.31)

1.97

 (1.44, 2.69)

- Plus adjustment for IGFBP-1 (log-transformed)

116

2.08

(1.31, 3.31)

1.96

(1.44, 2.69)

In participants with available free IGF-1

110

1.87

(1.18, 2.95)

1.52

 (1.11, 2.08)

- Plus adjustment for free IGF-1 (log-transformed)

110

1.83

(1.16, 2.91)

1.48

(1.08, 2.04)

- Plus adjustment for free to total IGF-1 (%, log-transformed)

110

1.85

(1.17, 2.95)

1.50

(1.10, 2.07)

  1. *adjusted for age, sex, BMI, and pretest and IGF-1/IGFBPs as indicated.
  2. ‡IGFBP-5 β estimates per log-transformed PAPP-A increment were back-transformed from the logarithmic to the original scale; back transformed estimates can be interpreted as x-fold IGFBP-5 concentrations associated with one unit higher log-transformed PAPP-A.
  3. Significant values are in bold.
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