Table 5 Multivariable adjusted* plasma concentrations of IGF-1 and IGF-binding protein concentrations by age- and sex-specific quintiles and continuously per increment of PAPP-A2 concentrations.

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

 

PAPP-A2

P-trend

β (95% CI) per 0.05 ng/mL§

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

IGF-1, ng/ml†

189.9

198.2

204.9

167.7

178.1

 

− 4.3

(175.8, 203.9)

(184.0, 212.3)

(191.7, 218.1)

(154.2, 181.1)

(164.5, 191.7)

0.009

(− 7.0, − 1.6)

Free IGF1 ठ(values above detection limit)

0.58

1.12

1.25

0.69

0.84

 

0.99

(0.41, 0.83)

(0.79, 1.59)

(0.90, 1.73)

(0.49, 0.95)

(0.61, 1.16)

0.75

(0.93, 1.06)

IGFBP-1, ng/mL‡║§

1.74

1.79

2.09

2.52

2.04

 

1.04

(1.32, 2.30)

(1.37, 2.35)

(1.60, 2.72)

(1.91, 3.31)

(1.57, 2.64)

0.179

(0.99, 1.09)

IGFBP-2, ng/mL†

295.6

319.3

309.3

343.7

384.4

 

11.9

(259.7, 331.5)

(283.1, 355.5)

(275.6, 343.1)

(309.3, 378.1)

(349.6, 419.2)

0.0002

(5.0, 18.8)

IGFBP-3, ng/mL†

3600

3594

3699

3370

3532

 

− 27.8

(3447, 3753)

(3439, 3748)

(3556, 3843)

(3224, 3517)

(3383, 3680)

0.15

(− 57.3, 1.8)

IGFBP-5, ng/mL‡§

15.0

35.4

19.5

23.1

21.2

 

0.97

(7.3, 30.9)

(16.8, 74.4)

(10.1, 37.7)

(11.5, 46.7)

(10.2, 44.2)

0.98

(0.85, 1.11

IGF-1/IGFBP-3 molar ratio, %†

19.2

19.8

20.2

18.0

18.3

 

− 0.34

(17.9, 20.5)

(18.5, 21.1)

(19.0, 21.5)

(16.8, 19.2)

(17.0, 19.6)

0.04

(− 0.59, − 0.09)

Free to total IGF-1 ratio, %‡§

0.31

0.57

0.63

0.41

0.50

 

1.03

(0.22, 0.44)

(0.40, 0.80)

(0.46, 0.87)

(0.30, 0.56)

(0.36, 0.68)

0.30

(0.97, 1.10)

PAPP-A, ng/mL ठ(values above detection limit)

6.10

7.84

7.60

7.49

7.07

 

1.01

(4.99, 7.46)

(6.38, 9.63)

(6.36, 9.09)

(6.19, 9.06)

(5.90, 8.47)

0.57

(0.98, 1.05)

PAPP-A, ng/mL‡§(values below detection limit substituted)

4.44

4.99

5.67

4.97

5.42

 

1.02

(3.61, 5.47)

(4.04, 6.15)

(4.66, 6.89)

(4.07, 6.07)

(4.43, 6.63)

0.37

(0.98, 1.06)

Stanniocalcin-2, ng/mL†

80.1

84.8

85.4

90.0

88.8

 

1.4

(73.7, 86.5)

(78.3, 91.3)

(79.4, 91.4)

(83.8, 96.1)

(82.6, 95.0)

0.03

(0.2, 2.6)

  1. N = 394, except for results on free IGF-1 (N = 339), IGFBP-1 (N = 360), IGFBP-5 (N = 125), and PAPP-A above detection limit (N = 288).
  2. *Adjusted for age, sex, BMI, and pretest.
  3. †Results for IGF-1, IGFBP-2, IGFBP-3, IGF-1:IGFBP-3 molar ratio and stanniocalcin-2 are means (95%-confidence intervals).
  4. ‡Results for IGFBP-1, IGFBP-5, free IGF-1, free to total IGF-1 ratio, and PAPP-A are geometric means (95%-confidence intervals).
  5. ║Models for IGFBP-1 were additionally adjusted for fasting status (≥ 6 h, yes vs no).
  6. §For IGFBP-1, IGFBP-5, free IGF-1, free to total IGF-1 ratio and PAPP-A β estimates per 0.5 ng/mL PAPP-A2 increment were back-transformed from the logarithmic to the original scale; back transformed estimates can be interpreted as x-fold IGFBP-1, IGFBP-5, free IGF-1 or PAPP-A concentrations or free to total IGF-1 ratio associated with 0.5 ng/mL higher PAPP-A2.
  7. Significant values are in bold.
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