Table 6 Associations of PAPP-A2 with IGF-1, IGF-1:IGFBP-3 molar ratio and IGFBP-2 with additional adjustment for other members of the system.

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

 

n

β per 0.05 ng/mL PAPP-A2 increment

95% CI

IGF-1, ng/ml

As in Table 5

394

− 4.3

(− 7.0, − 1.6)

- Plus adjustment for IGFBP-2

394

− 3.8

(− 6.5, − 1.0)

- Plus adjustment for IGFBP-3

394

− 3.1

(− 5.6, − 0.7)

In participants with available IGFBP-1

360

4.0

(− 6.8, − 1.2)

- Plus adjustment for IGFBP-1 (log-transformed)

360

− 3.3

(− 5.9, − 0.6)

In participants with available IGFBP-5

125

− 2.6

(− 7.5, 2.2)

- Plus adjustment for IGFBP-5 (log-transformed)

125

− 2.4

(− 7.2, 2.4)

In participants with available free IGF-1

125

− 4.5

(− 7.4, − 1.6)

- Plus adjustment for free IGF-1 (log-transformed)

339

− 4.3

(− 7.2, − 1.3)

IGF-1/IGFBP-3 molar ratio, %

As in Table 5

394

- 0.34

 (− 0.59, − 0.09)

- Plus adjustment for IGFBP-2

394

− 0.35

(− 0.60, − 0.09)

In participants with available IGFBP-1

360

- 0.33

(− 0.58, − 0.08)

- Plus adjustment for IGFBP-1 (log-transformed)

360

− 0.29

(− 0.53, − 0.04)

In participants with available IGFBP-5

125

- 0.13

(− 0.58, 0.32)

- Plus adjustment for IGFBP-5 (log-transformed)

125

− 0.11

(− 0.55, 0.33)

In participants with available free IGF-1

339

− 0.37

 (− 0.64, − 0.09)

- Plus adjustment for free IGF-1 (log-transformed)

339

− 0.37

(− 0.64, − 0.10)

IGFBP-2, ng/ml

As in Table 5

394

11.9

(5.0, 18.8)

- Plus adjustment for IGFBP-3

394

10.3

(3.6, 17.1)

- Plus adjustment for IGF-1

394

10.7

(3.7, 17.6)

In participants with available free IGF-1

339

11.1

(4.0, 18.2)

- Plus adjustment for free IGF-1 (log-transformed)

339

11.1

(4.1, 18.1)

- Plus adjustment for free to total IGF-1 (%, log-transformed)

339

11.5

(4.4, 18.5)

In participants with available IGFBP-1

360

10.9

(3.7, 18.0)

- Plus adjustment for IGFBP-1 (log-transformed)

360

9.2

(2.3, 16.2)

In participants with available IGFBP-5

125

4.9

(− 7.1, 17.0)

- Plus adjustment for IGFBP5 (log-transformed)

125

5.2

(− 6.9, 17.2)

  1. Model 1: adjusted for age, sex, BMI, and pretest and IGF-1/IGFBPs as indicated.
  2. Significant values are in bold.
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