Table 7 Multivariable adjusted* plasma concentrations of IGF-1 and IGF-binding protein concentrations by age- and sex-specific quintiles and continuously per increment of STC2 concentrations.

From: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population

 

STC2

P-trend

β (95% CI) per 10 ng/mL§

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

IGF-1, ng/ml†

187.0

188.8

186.6

194.8

179.1

 

− 2.4

(173.2, 200.8)

(174.8, 202.8)

(172.4, 200.7)

(180.6, 209.0)

(164.4, 193.8)

0.32

(− 4.7, − 0.2)

Free IGF1ठ(values above detection limit)

0.64

0.84

0.95

1.16

0.88

 

1.03

(0.45, 0.90)

(0.61, 1.16)

(0.67, 1.34)

(0.83, 1.62)

(0.61, 1.27)

0.26

(0.97, 1.09)

IGFBP-1, ng/mL‡║§

2.00

1.70

2.00

1.90

2.62

 

1.07

(1.54, 2.60)

(1.30, 2.23)

(1.52, 2.64)

(1.46, 2.48)

(1.98, 3.47)

0.02

(1.03, 1.10)

IGFBP-2, ng/mL†

345.7

368.7

322.2

317.4

296.8

 

− 8.9

(310.9, 380.5)

(333.4, 404.0)

(286.6, 357.9)

(281.7, 353.1)

(259.9, 333.8)

0.01

(− 14.5, − 3.3)

IGFBP-3, ng/mL†

3621

3543

3533

3607

3458

 

− 24.9

(3472, 3770)

(3392, 3694)

(3380, 3685)

(3455, 3760)

(3300, 3616)

0.23

(− 48.8, − 1.0)

IGFBP-5, ng/mL‡§

25.2

12.3

28.5

30.1

17.1

 

0.96

(12.9, 49.3)

(6.3, 24.2)

(14.7, 55.3)

(13.6, 66.6)

(7.6, 38.5)

0.97

(0.86, 1.08)

IGF-1/IGFBP-3 molar ratio, %†

18.7

19.3

19.3

19.4

18.9

 

− 0.09

(17.4, 20.0)

(18.0, 20.6)

(18.0, 20.6)

(18.1, 20.7)

(17.5, 20.2)

0.79

(− 0.29, 0.11)

Free to total IGF-1 ratio, %‡§

0.35

0.47

0.51

0.6

0.51

 

1.04

(0.25, 0.49)

(0.34, 0.65)

(0.37, 0.72)

(0.43, 0.83)

(0.36, 0.73)

0.15

(0.99, 1.10)

PAPP-A2, ng/mL†

0.25

0.27

0.26

0.29

0.30

 

0.00

(0.22, 0.27)

(0.25, 0.30)

(0.24, 0.29)

(0.27, 0.32)

(0.28, 0.33)

0.01

(0.00, 0.01)

PAPP-A, ng/mLठ(values above detection limit)

8.26

7.50

6.73

6.10

7.18

 

0.97

(6.90, 9.89)

(6.20, 9.06)

(5.53, 8.20)

(5.06, 7.35)

(5.80, 8.89)

0.16

(0.94, 1.01)

PAPP-A, ng/mLठ(values below detection limit substituted)

6.08

5.31

4.56

4.86

4.54

 

0.95

(4.98, 7.42)

(4.34, 6.50)

(3.71, 5.59)

(3.96, 5.96)

(3.68, 5.62)

0.02

(0.93, 0.99)

  1. N = 394, except for results on free IGF-1 (N = 339), IGFBP-1 (N = 360), IGFBP-5 (N = 125), and PAPP-A above detection limit (N = 288).
  2. *Adjusted for age, sex, BMI, and pretest.
  3. †Results for IGF-1, IGFBP-2, IGFBP-3, IGF-1/IGFBP-3 molar ratio and PAPP-A2 are means (95%-confidence intervals).
  4. ‡Results for IGFBP-1, IGFBP-5, free IGF-1, free to total IGF-1 ratio and PAPP-A are geometric means (95%-confidence intervals).
  5. ║Models for IGFBP-1 were additionally adjusted for fasting status (≥ 6 h, yes vs no).
  6. §IGFBP-1, IGFBP-5, free IGF-1, free to total IGF-1 ratio and PAPP-A estimates per 10 ng/mL STC2 increment on a logarithmic scale were back-tranformed.
  7. Significant values are in bold.
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