Table 3 Results of the MR-PRESSO method applied after excluding CRP genetic variants associated with BC risk (P < 0.05).

From: CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study

 

All BCa

ER + BCb

Beta

SE

P value

OR (95% CI)

Beta

SE

P value

OR (95% CI)

IVW (initial)

0.0457

0.0362

0.2059

1.05 (0.98,1.12)

0.0683

0.0456

0.1340

1.07 (0.98,1.17)

IVW (after outlier removal)

0.0558

0.0341

0.1020

1.06 (0.99,1.13)

0.0608

0.0382

0.1119

1.06 (0.99,1.15)

  1. IVW inverse-variance weighted, SE standard error, OR odds ratio, CI confidence interval.
  2. ER-BC absence of Outlier SNPs.
  3. aOutlier SNPs: rs13233571.
  4. bOutlier SNPs: rs1051338, rs2064009, rs9271608.