Figure 2
From: A gene expression-based classifier for HER2-low breast cancer
Identification of the 20 IHC category-specific genes and development of the HER2-low signature. a. The Venn diagram represents the number of specific and common genes for each HER2 IHC category, following their selection by the fold change and Wilcoxon test. The 12 genes identified in the INT1 dataset are in thin (3 genes in 1+, 8 genes in 2+ and one gene (CPLX1) in HER2-low); the 8 genes identified in the INT2 dataset are in bold; b. Partial correlation diagram and coefficient of the first principal component (PC) for the 20 IHC category-specific genes. The full order partial correlations between the 20 genes are visualized as a network, in which nodes represent genes and edges the dependencies between them. Thicker lines indicate higher correlation, with green lines representing positive correlations between genes and red lines indicating negative correlations. The HER2-low signature value was computed by combining the standardized expression of each gene with the pertinent first PC coefficient reported in the right part of the panel.
