Figure 3

Distribution of HER2-low signature values by HER2 IHC categories. a. Discovery; b. Confirmatory; and publicly available datasets, c.TCGA and d. GSE81538. Graphics report the distribution of the HER2-low signature values according to HER2 IHC categories: 0, HER2-low, and 3+ (left side); and 0, 1+, 2+, 3+ (right side). Each box indicates the 25th and 75th percentile. The horizontal lines inside the box indicate the median, whiskers indicate the extreme values. Discovery data set, excluding INT2 due to the absence of all IHC categories: HER2-low versus 0 (p = 0.0002) and versus 3+ (p = 0.0009); Confirmatory data set: HER2-low versus 0 (p = 0.0262) and versus 3+ (p = 0.0018); TCGA data set: HER2-low versus 0 (p value 0.049) and versus 3+ (p value 0.003) and GSE81538 data set: HER2-low versus 0 (p value 0.0005) and verus 3+ (p value < 0.0001).