Figure 2

Positive correlation between PD-L1 and HK2 in patients with HCC. (a) CD274 expression with low and high HK2 expression groups (50–75 percentile) in the Cancer Genome Atlas (TCGA) dataset of patients with HCC (n = 360). ***; p < 0.001. (b) CD274 expression with low and high SLC2A1 expression groups (50–75 percentile) in the TCGA dataset of patients with HCC (n = 360). ***; p < 0.001. (c) Immunohistochemistry was performed on a tissue microarray (with 24 patients) using PD-L1 (magenta pink) or HK2 (brown) antibodies. Co-staining was performed with both PD-L1 and HK2. Counterstaining was performed with hematoxylin. Scale bars: 50 μm. (d) Correlation between the PD-L1-positive area and HK2-positive area. Pearson’s correlation coefficient was used to calculate the correlation between the two factors.