Figure 5 | Scientific Reports

Figure 5

From: Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment

Figure 5

Administration of amnion epithelial cells modulates genes that are differentially expressed in the brain by angiotensin II-infusion. Volcano plot of differentially expressed genes in brains of mice infused with (A) vehicle versus angiotensin II or (B) angiotensin II versus angiotensin II + AECs. The threshold of differential expression is p-value < 0.05. The horizontal axis is the log2 fold change of genes. The vertical axis is statistical significance scaled as − log 10 p-value. Each dot represents an individual gene (blue: no significant difference; red: upregulated expression; green: downregulated expression). The top upregulated and downregulated genes in brains of mice infused with (C) vehicle versus angiotensin II or (D) angiotensin II versus angiotensin II + AECs (n = 6 per group). Upregulated genes in red and downregulated genes in blue. The colour scale represents the log10 (average FPKM + 1) value.

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