Table 1 List of the 8 miRNAs composing the plasmatic diagnostic signature, their stability, fold-changes (* = adjusted p-value < 0.05, ** = adjusted p-value < 0.01) and putative functions in literature.
From: microRNA blood signature for localized radiation injury
miRNA | Stability | Fold-change (irradiated vs control) | Putative function | References |
|---|---|---|---|---|
miR-18a-5p | 0.86 | 0.68** | Induction of keratinocytes apoptosis; disease markers of drug eruption in human | |
miR-139-5p | 1 | 0.55** | Regulation of inflammatory skin wound in mice | |
miR-146a-5p | 1 | 0.77* | Circulating radiation dosimeter for triage in NHPs | |
Circulating biomarker of WBI in mice | ||||
Regulation of inflammation in colon cancer cells | ||||
Anti-fibrotic effect after acute muscle contusion in mice and muscle cells | ||||
miR-148b-3p | 1 | 1.15 | Negative regulator of inflammatory gene expression in IgA vasculitis adult patients | |
miR-150-5p | 1 | 0.59** | Circulating biomarker of WBI in mice and patients | |
Circulating radiation dosimeter for triage in NHPs | ||||
Circulating biomarker of WBI in mice | ||||
Marker of radiation response in cancer patients | ||||
Reduction of inflammatory response and apoptosis of RAW264.7 macrophages after LPS stimulation | ||||
Promotion of wound healing in HaCat keratinocytes | ||||
miR-195a-5p | 1 | 0.98 | Implicated in UVB-induced acute skin injury in mice | |
Induces skeletal muscle wasting in C26 tumor bearing mice | ||||
miR-532-5p | 1 | 0.66** | Regulation of inflammation in childhood asthma | |
Regulation of inflammation in middle cerebral artery occlusion rat model | ||||
miR-342-3p | 0.86 | 2.08* | Circulating radiation dosimeter for triage in NHPs | |
Circulating indicator of WBI in mice |
