Figure 3

NK cell expansion and imbalance of polarized Th cell subsets characterizes COVID-19 disease in peds SOT. (A) Biaxial plot showing expansion of CD56⁺CD16⁻ NK cells during acute infection. Arrowheads pointing to CD16⁻ NK cells. Box plots showing summary data. The line in the middle of the box plot represents the median. (B) Biaxial plot showing expansion of CD4⁺ T cell (EM, Th2) during acute infection. Arrowheads pointing to the CD4⁺ T cell (EM, Th2) cell population. Box plots showing summary data. (C) Biaxial plot showing decreased frequency of B cell (non-switched memory) during acute infection. Arrowheads pointing to non-switched memory B cells. Box plots showing summary data. (D) Biaxial plot showing decreased frequency of CD8⁺ T cell (CM) during acute infection. Arrowheads pointing to CD8⁺ central memory cells. Box plots showing summary data. (E) Biaxial plot showing expansion of B cells (switched memory) during recovery. Arrowheads pointing to switched memory B cells. Box plots showing summary data. (F) Biaxial plot showing increased frequency of CD4⁻CD8⁻ T cells during recovery. Arrowheads pointing to CD4⁻CD8⁻ T cells. Box plots showing summary data. (G) Biaxial plot showing increased frequency of CD14⁺CD16⁻ classical monocytes during recovery. Arrowheads pointing to classical monocytes. Box plots showing summary data. (H) Biaxial plot showing decreased frequency of CD4⁺T cells (CM, Th17) during severe disease. Arrowheads pointing at CD4⁺T cells (CM, Th17). Box plots showing summary data. *p < 0.05 **p < 0.01.