Table 2 Prospective analysis of the association of 24 h urinary vanin-1 excretion with death-censored graft failure in 656 kidney transplant recipients.

From: Urinary vanin-1, tubular injury, and graft failure in kidney transplant recipients

 

Tertile 1

N = 219

 < 75 pmol/24 h

Tertile 2

N = 219

75–241.6 pmol/24 h

Tertile 3

N = 218

 > 241.6 pmol/24 h

Continuous (per doubling)

nevents

27

35

32

94

Model

 

HR (95%CI)

p-value

HR (95%CI)

p-value

HR (95%CI)

p-value

Crude

Ref

1.38 (0.83–2.27)

0.2

1.18 (0.70–1.98)

0.5

1.09 (0.99–1.20)

0.093

Model 1

Ref

1.47 (0.88–2.43)

0.1

1.23 (0.73–2.06)

0.4

1.09 (0.99–1.20)

0.073

Model 2

Ref

1.10 (0.66–1.83)

0.7

1.00 (0.60–1.68)

1.0

1.04 (0.93–1.16)

0.5

Model 3

Ref

0.90 (0.54–1.51)

0.7

0.72 (0.42–1.23)

0.2

0.96 (0.86–1.08)

0.5

Model 4

Ref

0.89 (0.53–1.50)

0.7

0.71 (0.41–1.21)

0.2

0.96 (0.86–1.07)

0.5

  1. Cox proportional-hazard regression analyses were performed to assess the association of 24h urinary vanin-1 excretion with the risk of death-censored graft failure (the need for re-transplantation or (re-)initiation of dialysis). Model 1 was adjusted for age, sex, and body surface area. Model 2 was further adjusted for the estimated glomerular filtration rate based on the creatinine-based CKD-EPI formula. Model 3 was further adjusted for 24-h urinary protein excretion. Model 4 was further adjusted for the use of proliferation inhibitors. 95% CI, 95% confidence interval; HR, hazard ratio.
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