Figure 6
No Effect of MSH3 di-siRNA treatment on nuclear HTT staining in HdhQ111/+ mice. (A) Representative immunofluorescence images showing Alexa Fluor 647 labelled HTT nuclear inclusions (EM48), Alexa Fluor 488 labelled DARP-32 and Hoechst staining in striatal sections of HdhQ111/+ mice at 3 months of age, untreated, treated with vehicle, 3 nmol di-siRNA, and 10 nmol di-siRNA at 6 months of age. (B) Quantification of the nuclear HTT staining index in the striatum. Error bars represent mean ± SD; n = 6–10. One-way ANOVA with Tukey’s post hoc analysis, ***p < 0.0001 and ****p < 0.0001.
