Table 2 Anticancer activity of the synthesized nanoformulae against colorectal (Caco-2) carcinoma.

From: In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

Trial number

Sericin/propolis ratio

Stirring time (min)

IC50 Concentration (µg/ml)

Physical characteristics

Zeta Potential (mV)

Size (nm)

PDI

1

1/1

15.0

94.40 ± 5.9

25.5

7540.0

0.27

2

1/1

30.0

53.14 ± 1.3

27.5

629.6

0.28

3

1/1

45.0

51.08 ± 0.9

35.6

166.1

0.65

4

1/1

60.0

32.09 ± 1.1

39.3

116.0

1.00

5

2/3

15.0

99.50 ± 6.7

28.6

1438.0

0.45

6

2/3

30.0

98.80 ± 3.7

33.3

642.3

0.47

7

2/3

45.0

87.80 ± 2.4

33.4

389.6

0.75

8

2/3

60.0

80.40 ± 10.7

40.4

143.2

0.97

9

1/2

15.0

284.24 ± 11.4

22.7

394.4

0.39

10

1/2

30.0

198.50 ± 12.3

23.0

362.8

0.41

11

1/2

45.0

184.04 ± 6.7

25.7

319.1

0.56

12

1/2

60.0

105.19 ± 0.8

27.2

270.3

0.46

13

3/2

15.0

47.38 ± 0.8

20.5

617.3

0.27

14

3/2

30.0

39.06 ± 1.9

23.0

375.0

0.31

15

3/2

45.0

35.01 ± 0.6

23.6

362.9

0.33

16

3/2

60.0

29.80 ± 1.7

24.8

269.9

0.36

17

2/1

15.0

68.20 ± 1.6

24.4

269.3

0.22

18

2/1

30.0

49.16 ± 2.4

28.2

268.0

0.24

19

2/1

45.0

47.20 ± 1.7

29.7

234.0

0.26

20

2/1

60.0

23.68 ± 2.6

32.7

222.6

0.30