Table 6 Determination of combination Index (CI).

From: In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

Combination trial

CI value

Dose Sericin

Dose Propolis

Dose 5-fluorouracil

Sericin (SE)

ND

1747.95

ND

ND

Propolis (PRO)

ND

ND

2518.12

ND

5-fluorouracil (FLU)

ND

ND

ND

25.8548

Sericin/Propolis (nSE/PRO)

1.37883

1422.62

1422.62

ND

Sericin/5-fluorouracil (SE/FLU)

0.92141

207.532

ND

20.7532

Propolis/5-fluorouracil (PRO/FLU)

0.96371

ND

225.965

22.5965

Sericin/Propolis/5-fluorouracil (nSE/PRO/FLU)

0.86381

178.585

178.585

17.8585

  1. ND: not detected.