Table 8 Apoptotic markers of colon tissue as affected by different treatments.

From: In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

Group

Caspase 9

Caspase 3

Bax

BCL2

TBARS

Treatments

Sham control

0.99 ± 0.01d

1.01 ± 0.105c

0.99 ± 0.02b

0.99 ± 0.02b

7.52 ± 0.4a

Positive control

0.15 ± 0.02a

0.07 ± 0.006a

0.21 ± 0.02a

1.254 ± 1.6j

28.91 ± 2.53c

Sericin

2.09 ± 0.01f.

2.32 ± 0.006d

1.39 ± 0.04e

1.1611 ± 2.9i

32.05 ± 1.93d

Propolis

1.33 ± 0.03e

0.77 ± 0.004b

1.12 ± 0.02c

1.0836 ± 3.4 h

34.6 ± 2.41d

Sericin/propolis nanoparticles

3.28 ± 0.05 h

2.31 ± 0.006d

1.62 ± 0.01f.

2.371 ± 1.4f.

16.6 ± 1.65b

Sericin/propolis/fluorouracil NPs

5.05 ± 0.03j

4.57 ± 0.003 g

8.16 ± 0.03i

5.188 ± 0.05d

26.6 ± 1.37c

Fluorouracil

3.89 ± 0.01i

4.26 ± 0.001f.

5.11 ± 0.02 h

3.45 ± 0.9e

24.1 ± 1.92c

Prophylactic

Sericin

0.71 ± 0.03c

4.21 ± 0.002f.

1.25 ± 0.05d

1.771 ± 0.04c

34.61 ± 1.54d

Propolis

0.59 ± 0.02b

2.77 ± 0.003e

0.96 ± 0.03b

0.3135 ± 0.09 g

31.48 ± 1.32d

Sericin/propolis nanoparticles

2.8 ± 0.02 g

6.51 ± 0.005 h

5.01 ± 0.01 g

0.76 ± 0.02a

23.58 ± 1.05c

  1. Data are represented as the mean ± SD. Within the row, means with different letter (a, b, c, etc.) are statistically significant at p < 0.05 while means with the same letter are significantly similar at p < 0.05. Mean with letter a is the lowest one followed by mean with b, c, etc.