Table 12 Drug combination datasets used to confirm our results (https://drugcomb.org/help/#line12).
From: Harnessing machine learning to find synergistic combinations for FDA-approved cancer drugs
Study name | Disease | Data source | Pubmed id | Number of drugs | Number of blocks | Number of cell lines | Number of tissues | Full dose–response matrix size |
|---|---|---|---|---|---|---|---|---|
ONEIL | Cancer | Publication | 26983881 | 38 | 92,208 | 39 | 6 | 5 × 5 |
CLOUD | Cancer | Publication | 28530711 | 283 | 40,160 | 1 | 1 | 2 × 2 |
ALMANAC | Cancer | Publication | 28446463 | 103 | 311,604 | 60 | 9 | 4 × 4, 4 × 6 |
FORCINA | Cancer | Publication | 28601558 | 1818 | 1818 | 1 | 1 | 2 × 2 |
NCATS_ATL | Cancer | NCATS Tripod | 22 | 30 | 1 | 1 | 10 × 10 | |
MATHEWS | Cancer | NCATS Tripod | 24469833 | 477 | 1119 | 1 | 1 | 6 × 6, 10 × 10 |
NCATS_DIPG | Cancer | NCATS Tripod | 2450 | 8854 | 2 | 2 | 6 × 6, 10 × 10 | |
NCATS_ES(FAKI/AURKI) | Cancer | NCATS Tripod | 1909 | 1910 | 1 | 1 | 6 × 6 | |
NCATS_ES(NAMPT + PARP) | Cancer | NCATS Tripod | 94 | 4628 | 4 | 3 | 6 × 6, 10 × 10 | |
WILSON | Cancer | NCATS Tripod | 30289729 | 31 | 764 | 2 | 1 | 6 × 6, 10 × 10 |
NCATS_HL | Cancer | NCATS Tripod | 1910 | 2694 | 4 | 2 | 6 × 6, 10 × 10 | |
YOHE | Cancer | NCATS Tripod | 29973406 | 25 | 270 | 3 | 2 | 10 × 10 |
NCATS_2D_3D | Cancer | NCATS Tripod | 5 | 70 | 2 | 2 | 10 × 10 | |
PHELAN | Cancer | NCATS Tripod | 29925955 | 16 | 62 | 1 | 1 | 10 × 10 |
NCATS_MDR_CS | Cancer | NCATS Tripod | 18 | 68 | 2 | 1 | 10 × 10 | |
CCLE | Cancer | PharmacoDB | 22460905 | 24 | 11,670 | 503 | 24 | 6 × 1, 7 × 1, 8 × 1 |
CTRPV2 | Cancer | PharmacoDB | 26482930 | 544 | 395,263 | 887 | 24 | 8 × 1 ~ 29 × 1 |
FIMM | Cancer | PharmacoDB | 24056683 | 52 | 2561 | 50 | 5 | 5 × 1 |
GCSI | Cancer | PharmacoDB | 27193678 | 16 | 6455 | 409 | 23 | 8 × 1, 9 × 1 |
GDSC1 | Cancer | PharmacoDB | 23180760 | 250 | 225,480 | 1074 | 30 | 5 × 1, 9 × 1 |
GRAY | Cancer | PharmacoDB | 24176112 | 89 | 9413 | 70 | 2 | 9 × 1 |
UHNBREAST | Cancer | PharmacoDB | 26771497 | 4 | 52 | 15 | 1 | 9 × 1, 18 × 1 |
BEATAML | Cancer | Publication | 30333627 | 122 | 59,348 | 528 | 1 | 7 × 1 |
FLOBAK | Cancer | Publication | 31664030 | 19 | 9984 | 8 | 7 | 6 × 6 |
ASTRAZENECA | Cancer | AstraZeneca | 31209238 | 116 | 20,482 | 153 | 10 | 6 × 6 |
FRIEDMAN | Cancer | Publication | 26461489 | 108 | 208,008 | 36 | 1 | 3 × 3 |
SCHMIDT | Cancer | Publication | 24101737 | 4 | 100 | 5 | 1 | 8 × 8 |
MILLER | Cancer | Publication | 24065146 | 13 | 82 | 1 | 1 | 8 × 8 |
FRIEDMAN2 | Cancer | Publication | 28446504 | 76 | 28,500 | 10 | 1 | 3 × 3 |
TOURET | SARS-CoV-2 | Publication | 32753646 | 1516 | 1520 | 1 | 1 | 1 × 1 |
GORDON | SARS-CoV-2 | Publication | 32353859 | 75 | 290 | 1 | 1 | 5 × 1, 6 × 1, 7 × 1 |
ELLINGER | SARS-CoV-2 | ChEMBL | 5604 | 5632 | 1 | 1 | 1 × 1 | |
MOTT | Malaria | NCATS Tripod | 26403635 | 223 | 17,072 | 3 | 1 | 6 × 6, 10 × 10 |
NCATS_SARS-COV-2DPI | SARS-CoV-2 | NCATS Tripod | 56 | 206 | 1 | 1 | 6 × 6 | |
BOBROWSKI | SARS-CoV-2 | NCATS Tripod | 32637956 | 34 | 262 | 1 | 1 | 6 × 6 |
DYALL | Ebola | NCATS Tripod | 29939303 | 17 | 432 | 2 | 2 | 6 × 6 |
FALLAHI-SICHANI | Cancer | Publication | 28069687 | 10 | 111 | 5 | 1 | 10 × 1, 20 × 1 |
