Table 2 Factors associated with overall survival in univariate and multivariate analyses of cirrhotic and non-cirrhotic HCC (N = 1654).

From: Cryptogenic non-cirrhotic HCC: Clinical, prognostic and immunologic aspects of an emerging HCC etiology

Parameters

Univariate analysis

 

Multivariate analysis

 
 

HR

95% CI

p value

HR

95% CI

p value

Age

1.017

1.011–1.023

< 0.0001

1.008

1.002–1.014

0.009

Sex (male)

0.916

0.793–1.058

0.234

   

Severe fibrosis (F3–F4)

1.034

0.893–1.197

0.658

1.398

1.144–1.681

< 0.0001

Etiology

  

0.001

  

0.037

 Cryptogenic

Reference

  

Reference

  

 Non-viral

0.808

0.657–0.995

 

0.783

0.603–1.017

 

 Viral

0.677

0.543–0.845

 

0.696

0.522–0.927

 

Tumor stage

  

< 0.0001

  

< 0.0001

 Early stage

Reference

  

Reference

  

 Intermediate stage

2.113

1.785–2.501

 

2.159

1.821–2.560

 

 Advanced stage

6.662

5.703–7.784

 

6.606

5.642–7.734

 

Diagnostic period

  

0.429

   

 2009–2012

Reference

     

 2013–2016

0.906

0.782–1.051

    

 2017–2020

0.947

0.810–1.107

    
  1. HR hazard ratio, CI confidence interval.
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