Table 3 Factors associated with overall survival in univariate and multivariate analyses of non-cirrhotic HCC (N = 371).

From: Cryptogenic non-cirrhotic HCC: Clinical, prognostic and immunologic aspects of an emerging HCC etiology

Parameters

Univariate analysis

 

Multivariate analysis

 

HR

95% CI

p value

HR

95% CI

p value

Age

1.021

1.010–1.031

< 0.0001

1.015

1.004–1.025

0.006

Sex (male)

0.809

0.606–1.081

0.153

   

Etiology

  

0.004

  

0.440

 Cryptogenic

Reference

  

Reference

  

 Non-viral

0.628

0.477–0.827

 

0.843

0.636–1.119

 

 Viral

0.688

0.441–1.074

 

0.825

0.523–1.301

 

Tumor stage

  

< 0.0001

  

0.003

 Early stage

Reference

  

Reference

  

 Intermediate stage

1.313

0.910–1.894

 

1.054

0.705–1.574

 

 Advanced stage

4.966

3.530–6.986

 

2.203

1.292–3.755

 

Treatment strategy

  

< 0.0001

  

< 0.0001

 Curative

Reference

  

Reference

  

 Non-curative

3.679

2.627–5.151

 

2.349

1.505–3.665

 

 Best supportive

5.583

4.037–7.721

 

2.524

1.496–4.260

 

Diagnostic period

  

0.883

   

 2009–2012

Reference

     

 2013–2016

1.053

0.759–1.460

    

 2017–2020

0.947

0.775–1.533

    
  1. HR hazard ratio, CI confidence interval.
Back to article page