Table 6 Toxicity prediction potential compound predicted by ProTox-II.
Endpoint | Target | ACE | HYP | ISO | CAG | ORO | CGA |
|---|---|---|---|---|---|---|---|
Organ toxicity | Hepatoxicity | Inactive | Inactive | Inactive | Inactive | Inactive | Inactive |
Toxicity end point | Carcinogenicity | Inactive | Inactive | Inactive | Inactive | Inactive | Inactive |
Immunotoxicity | Active | Active | Active | Active | Active | Active | |
Mutagenicity | Inactive | Inactive | Inactive | Inactive | Inactive | Inactive | |
Cytotoxicity | Inactive | Inactive | Inactive | Inactive | Inactive | Inactive | |
LD50 (mg/kg) | 5000 | 5000 | 5000 | 536 | 5000 | 536 | |
Toxicity class | 5 | 5 | 5 | 4 | 5 | 4 | |
Tox21-nuclear receptor signaling pathways | Aryl hydrocarbon receptor (AhR) | Inactive | Inactive | Inactive | Inactive | Inactive | Inactive |
Androgen receptor (AR) | Inactive | Inactive | Inactive | Active | Inactive | Active | |
Tox21-stress pathways | Heat shock factor response element (HSE) | Inactive | Inactive | Inactive | Inactive | Inactive | Inactive |
