Figure 3 | Scientific Reports

Figure 3

From: NDUFS7 variant in dogs with Leigh syndrome and its functional validation in a Drosophila melanogaster model

Figure 3

Brain, corresponding imaging (transverse T2-weighted MRI images; A,E), gross pathology (fixed brain; B,F) and histopathology (H&E stain; C,D and G,H) of case 1. (A–D) lesions in caudate nucleus (arrows), (E–H) lesions in caudal colliculi (arrows) and lateral lemnisci (thin arrows), with D close-up of lesion in caudate nucleus (asterisk indicates internal capsule in C and D) and H close-up of lesion in left caudal colliculus (asterisk in G). The lesion in the caudate nucleus, difficult to appreciate on gross examination (B), is characterized by vascular proliferation (D), whilst those in the caudal colliculi and lateral lemnisci exhibit a substantial loss of the neuropil and cavitation, with sparing of individual intralesional neurons (H, arrows).

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