Table 3 OR (95%CI) for the association between the preoperative serum LDH level and in-hospital mortality, ICU admission, and MINS in all patients and subgroups.

From: The impact of preoperative serum lactate dehydrogenase on mortality and morbidity after noncardiac surgery

Mortality

LDH <  = 220

LDH > 220

P-Value

N (%)

821 (0.702%)

611 (4.382%)

 

ORunadj

Reference

4.938 (4.447,5.482)

 < 0.001

ORlrm-adj

Reference

1.856 (1.620,2.127)

 < 0.001

ORIPTW-adj

Reference

1.814 (1.676,1.962)

 < 0.001

Strata ORlrm-adj

 Sex

  Men (n = 66,561)

Reference

1.790 (1.507,2.125)

 < 0.001

  Women (n = 64,318)

Reference

1.918 (1.529,2.405)

 < 0.001

 Age

  14–60 (n = 91,352)

Reference

1.863 (1.546,2.243)

 < 0.001

  > 60 years (n = 39,527)

Reference

1.877 (1.532,2.301)

 < 0.001

 ASA-PS

  I–II (n = 96,406)

Reference

1.838 (1.263,2.675)

0.001

  III (n = 32,818)

Reference

1.525 (1.195,1.944)

0.001

  IV–V (1655)

Reference

2.029 (1.693,2.430)

 < 0.001

 Emergency case

  Emergency (n = 8362)

Reference

1.656 (1.387,1.976)

 < 0.001

  Elective (n = 122,517)

Reference

2.047 (1.661,2.522)

 < 0.001

 General anaesthesia

  Yes (n = 123,382)

Reference

1.827 (1.587,2.102)

 < 0.001

  No (n = 7497)

Reference

2.263 (1.222,4.192)

0.009

 Comorbid diseases

  Hypertension

   Yes (n = 22,644)

Reference

1.705 (1.332,2.181)

 < 0.001

   No (n = 108,235)

Reference

1.895 (1.607,2.234)

 < 0.001

  Ischemic heart disease

   Yes (n = 3373)

Reference

1.444 (0.773,2.700)

0.249

   No (n = 127,506)

Reference

1.890 (1.643,2.174)

 < 0.001

  Diabetes

   Yes (n = 9379)

Reference

1.523 (1.065,2.178)

0.021

   No (n = 121,500)

Reference

1.907 (1.644,2.211)

 < 0.001

  COPD

   Yes (n = 5720)

Reference

2.322 (1.560,3.455)

 < 0.001

   No (n = 125,159)

Reference

1.789 (1.546,2.070)

 < 0.001

  Liver disease

   Yes (n = 22,891)

Reference

1.960 (1.502,2.556)

 < 0.001

   No (n = 107,988)

Reference

1.789 (1.524,2.100)

 < 0.001

  Renal failure

   Yes (n = 3661)

Reference

1.672 (1.025,2.726)

0.039

   No (n = 127,218)

Reference

1.863 (1.615,2.149)

 < 0.001

  Malignancy tumor

   Yes (n = 40,391)

Reference

1.926 (1.448,2.562)

 < 0.001

   No (n = 90,488)

Reference

1.819 (1.557,2.127)

 < 0.001

 Surgery sites

  Central Nervous System (n = 11,533 )

Reference

1.770 (1.417,2.211)

 < 0.001

  Bones and Muscles (n = 21,615 )

Reference

1.171 (1.069,1.986)

0.020

  Pulmonary and Vascular (n = 13,872 )

Reference

1.664 (1.092,3.025)

0.015

  Gastrointestinal Tract, Biliary Tract, Pancreas, and Liver (n = 36,127 )

Reference

2.089 (1.635,2.669)

 < 0.001

  Breast, Thyroid, Otolaryngology, Head and Neck, Skin and Soft Tissue (n = 25,007 )

Reference

2.114 (1.097,4.589)

0.015

ICU admission

LDH <  = 220

LDH > 220

P-Value

 N (%)

7500 (6.414%)

2093 (15.010%)

 

 ORunadj

Reference

2.577 (2.446,2.715)

 < 0.001

 ORlrm-adj

Reference

1.765 (1.642,1.896)

 < 0.001

 ORIPTW-adj

Reference

1.596 (1.542,1.651)

 < 0.001

MINS

LDH <  = 220

LDH > 220

P-Value

 N (%)

628 (0.537%)

420 (3.012%)

 

 ORunadj

Reference

5.752 (5.077,6.516)

 < 0.001

 ORlrm-adj

Reference

1.911 (1.643,2.223)

 < 0.001

 ORIPTW-adj

Reference

1.815 (1.664,1.98)

 < 0.001

  1. OR Odds ratios.
  2. Note: Unadjusted Model (ORunadj): The unadjusted odds ratio was calculated using a logistic regression model without additional covariate adjustments. Adjusted Logistic Regression Model (ORlrm-adj): Odds ratios were adjusted for relevant covariates using a multivariable logistic regression model. IPTW-Assisted Adjusted Model (ORIPTW-adj): Inverse Probability of Treatment Weighting (IPTW) was applied to adjust for treatment selection bias, and odds ratios were estimated using a multivariable logistic regression model. Subgroup analyses were performed to assess the relationship between LDH and mortality outcomes within various subpopulations.
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