Table 2 Coefficients and P-values of the prediction models.

From: Quality-by-design ecofriendly potentiometric sensor for rapid monitoring of hydroxychloroquine purity in the presence of toxic impurities

 

Intercept

A

B

C

AB

AC

BC

ABC

Slope

27.39

0.795

0.1225

2.4

0.35125

2.14375

− 1.03625

2.0625

P-value

 

0.0128

0.6364

< 0.0001

0.1966

< 0.0001

0.0032

< 0.0001

r

0.99

8.75 × 10–5

− 0.00062

− 0.00136

− 0.00301

− 0.00314

  

P-value

 

0.9438

0.6217

0.2888

0.0324

0.0267

  

pLOQ

5.97

− 2.22 × 10–16

− 2.22 × 10–16

− 2.22 × 10–16

2.22 × 10–16

2.22 × 10–16

2.22 × 10–16

− 2.22 × 10–16

P-value

 

0.3466

0.3466

0.3466

0.3466

0.3466

0.3466

0.3466

\({K}_{HCQ, DCQ}^{pot}\)

2.7 × 10–4

2.98 × 10–5

− 2.59 × 10–5

 

− 2.2 × 10–4

   

P-value

 

0.5639

0.6154

 

0.0008

   

Response time

7.06

− 1.3125

− 0.3125

− 0.6875

0.0625

0.9375

0.1875

 

P-value

 

0.0012

0.2987

0.0382

0.8304

0.0091

0.5247

 

\({K}_{HCQ, HND}^{pot}\)

7.61 × 10–4

− 8.68 × 10–5

2.74 × 10–4

3.42 × 10–4

 

− 1.9 × 10–4

2.81 × 10–4

 

P-value

 

0.3082

0.0069

0.0017

 

0.0389

0.0060

 
  1. Factors: A = Ion-exchanger, B = Ionophore, and C = Plasticizer.
  2. The underlined values represent the coefficients and P-values of the statistically significant factors.
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