Table 5 Cytotoxic activity of novel azepine derivatives against cancer and normal cell lines.

From: Synthesis and molecular docking simulations of novel azepines based on quinazolinone moiety as prospective antimicrobial and antitumor hedgehog signaling inhibitors

Compounds

In-vitro Cytotoxicity IC50 (μM)*

WI38

HCT-116

HepG-2

MCF-7

Anticancer GANT-61 (HH) reference inhibitor

55.03 ± 3.1

10.19 ± 0.3

21.90 ± 0.2

14.67 ± 0.2

Diazepine (3a)

168.08 ± 3.5

14.25 ± 1.1

24.57 ± 1.8

19.21 ± 0.8

Oxazepine (4a)

172.04 ± 3.7

16.95 ± 2.4

34.23 ± 2.0

28.28 ± 1.4

  1. *IC50 (μM): 1–10 (very strong). 11–30 (strong). 31–60 (moderate). 61–100 (weak) and above 100 (non-cytotoxic).
Back to article page