Figure 5 | Scientific Reports

Figure 5

From: Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

Figure 5

Human glia and neurons detected in mice cerebella six months after Control and MJD iPSC-derived NESC transplantation. (A-D and H-J) Control and (E–G and K-M) MJD CLA iPSC-derived NESC expressing GFP (green) were detected in the cerebellum six months after transplantation. (A) Representative fluorescence image illustrating the limited migration of the grafted cells (green) in the adult cerebellum. Representative immunofluorescence confocal microscopy images of (B-G) GFAP (red) and (H-M) MAP2 (red) labeling. Images show that six months after cell transplantation, Control (CNT) and MJD CLA iPSC-derived NESC grafts have GFAP-positive glial cells and MAP2-positive neurons showed by the colocalization between GFP and GFAP and MAP2, respectively. DAPI: blue, n = 3 mice/group, scale bars: (A) 200 μm, (B-M) 100 μm.

Back to article page