Figure 3

Integration analysis using Seurat. (A) Scatter plot of Uniform Manifold Approximation and Projection results. (B) Heatmap of the top 10 marker genes of each cluster. In total, 8 clusters were identified by the integration analysis, and then characterized based on their marker genes as lipid leaden macrophages (LLM), connective tissue, vascular regions, myositis, and 4 distinct myofiber (M1–M4) clusters.