Figure 5 | Scientific Reports

Figure 5

From: Spatial transcriptomics reveals alterations in perivascular macrophage lipid metabolism in the onset of Wooden Breast myopathy in broiler chickens

Figure 5

Proposed mechanism of lipid laden macrophage accumulation in the p. major muscle of broiler chickens. Cells are metabolically stimulated by oxidized low-density lipoproteins to activate PPARγ signaling pathway, which boosts lipid uptake and synthesis intracellularly to process excessive surrounding lipids. [oxLDL: oxidized low-density lipoproteins; FA: fatty acids; TAG: triacylglycerol; FC: free cholesterol; CE: cholesterol ester; CD36: CD36 molecule; NPC2: NPC intracellular cholesterol transporter 2; FABP4: Fatty Acid Binding Protein 4; PPARγ: peroxisome proliferator activated receptor gamma; PLIN1,4: Perilipin 1, 4; DGAT2: diacylglycerol O-acyltransferase 2; SCD: stearoyl-CoA desaturase; ACSL1: acyl-CoA synthetase long chain family member 1].

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